{"id":2126,"date":"2024-11-12T09:23:05","date_gmt":"2024-11-12T09:23:05","guid":{"rendered":"https:\/\/live-champs-new.pantheonsite.io\/?post_type=resource&p=2126"},"modified":"2024-11-17T15:46:27","modified_gmt":"2024-11-17T15:46:27","slug":"a-malnourished-infant-that-died-with-hiv-complicated-by-gastroenteritis-and-sepsis-caused-by-bacterial-and-fungal-infections","status":"publish","type":"resource","link":"https:\/\/champshealth.org\/resource\/a-malnourished-infant-that-died-with-hiv-complicated-by-gastroenteritis-and-sepsis-caused-by-bacterial-and-fungal-infections\/","title":{"rendered":"A malnourished infant that died with HIV, complicated by gastroenteritis and sepsis caused by bacterial and fungal infections"},"content":{"rendered":"\n
<\/span>\"\"
\n

CHAMPS RESOURCES<\/p>\n\n\n\n

CHAMPS Resources<\/h2>\n<\/div><\/div>\n\n\n\n
\n

A 1-year-old baby with a history of tuberculosis<\/strong> (TB) was undergoing treatment through the Ministry of Health TB program when she became ill with a fever, cough, frequent stool, and lack of appetite. The baby\u2019s symptoms did not stop despite treatment at home, so after 3 days, her mother decided to take her to an urban health facility. The healthcare workers documented generalized body wasting<\/strong> and visible prominence of ribs and other bones.  She was diagnosed with Severe Acute Malnutrition<\/strong> and was admitted for further management. Her condition worsened during her hospitalization despite nutritional support and antibiotic treatment, prompting concern of another unknown underlying condition.  She was tested and confirmed positive for HIV<\/strong> and died a few days later. After the infant\u2019s death, the mother confided that she was HIV positive and taking antiretrovirals<\/strong>; she initially kept her status private.<\/p>\n\n\n\n

Uncovering the Cause<\/h2>\n\n\n\n
\n\n\n\n

Measurements carried out by the CHAMPS team confirmed the infant\u2019s severe malnutrition, and CHAMPS laboratory tests confirmed her positive HIV status. Pathology test results showed that her liver had decreased bile flow, or cholestasis, and had undergone fatty changes, further indicating malnutrition as well as infection.<\/p>\n\n\n\n

CHAMPS laboratory tests also revealed a mixed bacterial and fungal infection in the lungs caused by Klebsiella pneumoniae<\/em><\/strong> and Candida albicans<\/em><\/strong>. These pathogens were found in both lung tissue and blood samples.<\/p>\n\n\n\n

The HIV infection weakened the infant\u2019s immune system making her susceptible to overwhelming infections, including gastroenteritis which was ultimately responsible for her death. The presence of malnutrition<\/strong> further exacerbated these issues and outcome.<\/p>\n\n\n\n

Pathology images<\/h2>\n\n\n\n
\n\n\n\n

Lung:<\/strong><\/p>\n<\/div><\/div>\n\n\n

\n
\"\"
Aspiration pneumonia with CI contents (arrowhead), and pseudohyphal and yeast-like forms (arrow)<\/strong><\/figcaption><\/figure><\/div>\n\n
\n
\"\"
Immunostaining by select gram-negative bacterial IHC assay that detects\u00a0Klebsiella pneumonia\u00a0(circle)<\/strong><\/figcaption><\/figure><\/div>\n\n
\n
\"\"
Extensive immunostaining of\u00a0Candida spp.\u00a0within intra-alveolar space and interstitium (circle)<\/strong><\/figcaption><\/figure><\/div>\n\n\n

Liver:<\/strong><\/p>\n\n\n

\n
\"\"
Liver sample showing fatty changes (steatosis) from severe metabolic changes associated with malnutrition (circle) and cholestasis (arrow)<\/strong><\/figcaption><\/figure><\/div>\n\n\n

Family Follow-up<\/h2>\n\n\n\n
\n\n\n\n

The team had a difficult time connecting with this mother, as she relocated to another district. The mother received the information on her baby\u2019s status with mixed emotion. She was with a new partner and pregnant with another child. Her current partner was unaware of her HIV status. The District Health HIV counselor encouraged the mother to comply with public health practices. She attended prevention of mother-to-child transmission (PMTCT) and took medication with the aim of protecting her next child.<\/p>\n\n\n\n

Public Health Implications<\/h2>\n\n\n\n
\n\n\n\n

CHAMPS findings highlighted the need to address HIV stigma<\/strong>, as the mother did not provide her own status to clinical workers as well as did not recognize the connection between her own status and the baby\u2019s illness.<\/p>\n\n\n\n

CHAMPS routinely refers HIV-positive mothers to readily available PMTCT programs as part of pregnancy surveillance. Referrals to this type of program should ideally occur before women become pregnant, and certainly before labor and delivery.<\/p>\n\n\n\n

This case also highlighted that, at multiple times, this baby entered the healthcare system for vaccinations, illness, and TB management, but was never identified as malnourished, referred to nutrition programs, or tested for HIV.<\/strong> The symptoms present in this case should have triggered HIV testing earlier, emphasizing the need to improve quality of care and clinical case management.<\/p>\n\n\n\n

\n\n\n\n

Interested in more CHAMPS updates?<\/strong><\/p>\n\n\n\n

Sign up for our mailing list!<\/a><\/p>\n\n\n\n

Email data@champshealth.org<\/a> for information about CHAMPS pathology slide images.<\/p>\n\n\n

\n\n

April 28, 2022 <\/p>\n\n

\n\nShare: <\/span>