{"id":2170,"date":"2024-11-12T14:29:53","date_gmt":"2024-11-12T14:29:53","guid":{"rendered":"https:\/\/live-champs-new.pantheonsite.io\/?post_type=resource&#038;p=2170"},"modified":"2024-11-18T10:32:08","modified_gmt":"2024-11-18T10:32:08","slug":"a-child-who-died-of-cerebral-malaria-complicated-by-a-serious-undiagnosed-bacterial-infection","status":"publish","type":"resource","link":"https:\/\/champshealth.org\/resource\/a-child-who-died-of-cerebral-malaria-complicated-by-a-serious-undiagnosed-bacterial-infection\/","title":{"rendered":"A child who died of cerebral malaria complicated by a serious undiagnosed bacterial infection"},"content":{"rendered":"\n<div class=\"wp-block-cover alignfull page-header-standard\"><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim-70 has-background-dim\" style=\"background-color:#6c695b\"><\/span><img loading=\"lazy\" decoding=\"async\" width=\"2560\" height=\"1707\" class=\"wp-block-cover__image-background wp-image-2171\" alt=\"\" src=\"https:\/\/live-champs-new.pantheonsite.io\/wp-content\/uploads\/2024\/11\/AdobeStock_80696320-scaled-1.jpg\" data-object-fit=\"cover\" srcset=\"https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/AdobeStock_80696320-scaled-1.jpg 2560w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/AdobeStock_80696320-scaled-1-300x200.jpg 300w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/AdobeStock_80696320-scaled-1-1024x683.jpg 1024w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/AdobeStock_80696320-scaled-1-768x512.jpg 768w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/AdobeStock_80696320-scaled-1-1536x1024.jpg 1536w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/AdobeStock_80696320-scaled-1-2048x1366.jpg 2048w\" sizes=\"auto, (max-width: 2560px) 100vw, 2560px\" \/><div class=\"wp-block-cover__inner-container is-layout-flow wp-block-cover-is-layout-flow\">\n<p class=\"has-text-align-center\">CHAMPS RESOURCES<\/p>\n\n\n\n<h2 class=\"wp-block-heading text-center\">CHAMPS Resources<\/h2>\n<\/div><\/div>\n\n\n<div class=\"publication-meta\"> \n\n<p class=\"publication-date\"> October 23, 2018 <\/p>\n\n<div class=\"publication-share\">\n\n<span class=\"share\">Share: <\/span> <ul> \n\n<li class=\"publication-share-facebook\"> <a href=\"\"> <i class=\"fa fa-facebook\"> <\/i> <\/a><\/li>\n<li class=\"publication-share-facebook\"> <a href=\"\"> <i class=\"fa-brands fa-x-twitter\"><\/i> <\/a><\/li>\n<li class=\"publication-share-instagran\"> <a href=\"\"> <i class=\"fa-brands fa-instagram\"><\/i> <\/a><\/li>\n\n<\/ul>\n <\/div>\n <\/div>\n\n <p class=\"publication-title\">A child who died of cerebral malaria complicated by a serious undiagnosed bacterial infection <\/p>\n\n\n<div class=\"wp-block-group pad-4 content-grey has-background\" style=\"background-color:#E6E6E6\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-columns w-65 margin-auto is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/live-champs-new.pantheonsite.io\/wp-content\/uploads\/2024\/11\/AdobeStock_80696320-scaled-1-1024x683.jpg\" alt=\"\" class=\"wp-image-2171\" srcset=\"https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/AdobeStock_80696320-scaled-1-1024x683.jpg 1024w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/AdobeStock_80696320-scaled-1-300x200.jpg 300w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/AdobeStock_80696320-scaled-1-768x512.jpg 768w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/AdobeStock_80696320-scaled-1-1536x1024.jpg 1536w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/AdobeStock_80696320-scaled-1-2048x1366.jpg 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column case-example-intro is-layout-flow wp-block-column-is-layout-flow\">\n<p>A&nbsp;<strong>three year old boy<\/strong>&nbsp;came to a health center after 3 days of fever, severe headache, vomiting and thirst.&nbsp; He was&nbsp;<strong>diagnosed with malaria<\/strong>&nbsp;and started on malaria treatment.<\/p>\n\n\n\n<p>However, he&nbsp;<strong>kept getting worse<\/strong>&nbsp;over the next day. He was sent from the health center to a referral hospital. When he arrived at the hospital, he was unresponsive and could not be resuscitated.<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group content-white\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-group case-uncovering-causes\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading has-text-align-left w-65 margin-auto\">Uncovering the Cause<\/h2>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>CHAMPS laboratory tests&nbsp;<strong>confirmed the presence of&nbsp;<em>Plasmodium falciparum<\/em>&nbsp;malaria<\/strong>. The child\u2019s blood culture after death was positive for three different bacteria, including&nbsp;<em>Streptococcus pneumoniae<\/em>. Tests of his blood and tissues also showed evidence of several organisms. In this case, pathologists examined the child\u2019s tissues and determined that&nbsp;<strong>the true cause of his serious bacterial infection was&nbsp;<em>Streptococcus pneumoniae<\/em><\/strong>&nbsp;in addition to confirming the diagnosis of malaria caused by&nbsp;<em>Plasmodium falciparum.<\/em><br><em>&nbsp;<\/em><\/p>\n\n\n\n<p class=\"has-text-align-left w-65 margin-auto\">CHAMPS confirmed that this young boy\u2019s cause of death was cerebral malaria along with a serious bacterial infection that complicated his course.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"375\" src=\"https:\/\/live-champs-new.pantheonsite.io\/wp-content\/uploads\/2024\/11\/Quote-Case-3-2-1024x375.png\" alt=\"\" class=\"wp-image-2178\" srcset=\"https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/Quote-Case-3-2-1024x375.png 1024w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/Quote-Case-3-2-300x110.png 300w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/Quote-Case-3-2-768x281.png 768w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/Quote-Case-3-2-1536x562.png 1536w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/Quote-Case-3-2.png 1902w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div><\/div><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Pathology images<\/h2>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n<\/div><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"767\" src=\"https:\/\/live-champs-new.pantheonsite.io\/wp-content\/uploads\/2024\/11\/2017-0418-IHC-40X-Plasmodium-falciparum-liver-1024x767.png\" alt=\"\" class=\"wp-image-2176\" srcset=\"https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/2017-0418-IHC-40X-Plasmodium-falciparum-liver-1024x767.png 1024w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/2017-0418-IHC-40X-Plasmodium-falciparum-liver-300x225.png 300w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/2017-0418-IHC-40X-Plasmodium-falciparum-liver-768x575.png 768w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/2017-0418-IHC-40X-Plasmodium-falciparum-liver.png 1388w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">Abundant malaria pigment (brown) in the liver<\/figcaption><\/figure><\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"767\" src=\"https:\/\/live-champs-new.pantheonsite.io\/wp-content\/uploads\/2024\/11\/2017-0418-HE10X-Liver-1024x767.png\" alt=\"\" class=\"wp-image-2174\" srcset=\"https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/2017-0418-HE10X-Liver-1024x767.png 1024w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/2017-0418-HE10X-Liver-300x225.png 300w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/2017-0418-HE10X-Liver-768x575.png 768w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/2017-0418-HE10X-Liver.png 1388w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">Plasmodium falciparum malaria parasites staining by immunohistochemistry in the liver<\/figcaption><\/figure><\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"767\" src=\"https:\/\/live-champs-new.pantheonsite.io\/wp-content\/uploads\/2024\/11\/2017-0418-IHC-40X-Plasmodium-falciparum-Brain-arrow-1024x767.png\" alt=\"\" class=\"wp-image-2175\" srcset=\"https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/2017-0418-IHC-40X-Plasmodium-falciparum-Brain-arrow-1024x767.png 1024w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/2017-0418-IHC-40X-Plasmodium-falciparum-Brain-arrow-300x225.png 300w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/2017-0418-IHC-40X-Plasmodium-falciparum-Brain-arrow-768x575.png 768w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/2017-0418-IHC-40X-Plasmodium-falciparum-Brain-arrow.png 1388w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">Plasmodium falciparum staining by immunohistochemistry within red blood cells in small blood vessels in the brain<\/figcaption><\/figure><\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/live-champs-new.pantheonsite.io\/wp-content\/uploads\/2024\/11\/2017-0418-HE-20X-Left-lung-arrow-1024x683.png\" alt=\"\" class=\"wp-image-2172\" srcset=\"https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/2017-0418-HE-20X-Left-lung-arrow-1024x683.png 1024w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/2017-0418-HE-20X-Left-lung-arrow-300x200.png 300w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/2017-0418-HE-20X-Left-lung-arrow-768x512.png 768w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/2017-0418-HE-20X-Left-lung-arrow-1536x1024.png 1536w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/2017-0418-HE-20X-Left-lung-arrow.png 1650w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">Increased leukocytes within a blood vessel in the lung (arrow)<\/figcaption><\/figure><\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"767\" src=\"https:\/\/live-champs-new.pantheonsite.io\/wp-content\/uploads\/2024\/11\/2017-0418-HE-63X-Liver-arrow-1024x767.png\" alt=\"\" class=\"wp-image-2173\" srcset=\"https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/2017-0418-HE-63X-Liver-arrow-1024x767.png 1024w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/2017-0418-HE-63X-Liver-arrow-300x225.png 300w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/2017-0418-HE-63X-Liver-arrow-768x576.png 768w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/2017-0418-HE-63X-Liver-arrow.png 1501w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">Malaria parasites within a red blood cell in the brain (arrow)<\/figcaption><\/figure><\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/live-champs-new.pantheonsite.io\/wp-content\/uploads\/2024\/11\/2017-0418-IHC-40x-Streptococcus-spp.-Left-lung-arrow-1024x683.png\" alt=\"\" class=\"wp-image-2177\" srcset=\"https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/2017-0418-IHC-40x-Streptococcus-spp.-Left-lung-arrow-1024x683.png 1024w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/2017-0418-IHC-40x-Streptococcus-spp.-Left-lung-arrow-300x200.png 300w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/2017-0418-IHC-40x-Streptococcus-spp.-Left-lung-arrow-768x512.png 768w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/2017-0418-IHC-40x-Streptococcus-spp.-Left-lung-arrow-1536x1024.png 1536w, https:\/\/champshealth.org\/wp-content\/uploads\/2024\/11\/2017-0418-IHC-40x-Streptococcus-spp.-Left-lung-arrow.png 1650w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">Clusters of Streptococcus bacteria seen in the lung by immunohistochemistry (arrows)<\/figcaption><\/figure><\/div>\n\n\n<div class=\"wp-block-group case-public-health\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading\">Public Health Implications<\/h2>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>Malaria remains an important cause of child mortality for previously healthy children in much of the world. Efforts are ongoing to prevent children from getting malaria. When children do get malaria,<a href=\"http:\/\/www.who.int\/malaria\/publications\/atoz\/who-severe-malaria-tmih-supplement-2014.pdf\">the World Health Organization (WHO) recommends<\/a>&nbsp;that those who have signs of severe malaria receive antibiotics for the possible complication of serious bacterial infection in addition to malaria medication. Children with severe malaria may also need faster transfer of their care to a referral facility if they are stable. This case shows the importance of rapid recognition of severe malaria so that appropriate care can be given.<\/p>\n<\/div><\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"has-text-align-center\"><strong>Interested in CHAMPS\u2019s pathology slide images?<br><\/strong>Email&nbsp;<a href=\"mailto:data@champshealth.org\">data@champshealth.org<\/a>&nbsp;to learn more!&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A&nbsp;three year old boy&nbsp;came to a health center after 3 days of fever, severe headache, vomiting and thirst.&nbsp; He was&nbsp;diagnosed with malaria&nbsp;and started on malaria treatment. However, he&nbsp;kept getting worse&nbsp;over the next day. He was sent from the health center to a referral hospital. When he arrived at the hospital, he was unresponsive and could [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/champshealth.org\/resource\/a-child-who-died-of-cerebral-malaria-complicated-by-a-serious-undiagnosed-bacterial-infection\/\">Read More&#8230;<span class=\"screen-reader-text\"> from A child who died of cerebral malaria complicated by a serious undiagnosed bacterial infection<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":2171,"parent":0,"template":"","meta":{"_acf_changed":false,"footnotes":""},"tags":[],"resource_category":[9],"class_list":["post-2170","resource","type-resource","status-publish","has-post-thumbnail","hentry","resource_category-case-example"],"acf":[],"_links":{"self":[{"href":"https:\/\/champshealth.org\/wp-json\/wp\/v2\/resource\/2170","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/champshealth.org\/wp-json\/wp\/v2\/resource"}],"about":[{"href":"https:\/\/champshealth.org\/wp-json\/wp\/v2\/types\/resource"}],"author":[{"embeddable":true,"href":"https:\/\/champshealth.org\/wp-json\/wp\/v2\/users\/3"}],"version-history":[{"count":8,"href":"https:\/\/champshealth.org\/wp-json\/wp\/v2\/resource\/2170\/revisions"}],"predecessor-version":[{"id":2363,"href":"https:\/\/champshealth.org\/wp-json\/wp\/v2\/resource\/2170\/revisions\/2363"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/champshealth.org\/wp-json\/wp\/v2\/media\/2171"}],"wp:attachment":[{"href":"https:\/\/champshealth.org\/wp-json\/wp\/v2\/media?parent=2170"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/champshealth.org\/wp-json\/wp\/v2\/tags?post=2170"},{"taxonomy":"resource_category","embeddable":true,"href":"https:\/\/champshealth.org\/wp-json\/wp\/v2\/resource_category?post=2170"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}